Germinated grain was used in China not only for food but for medicine 5000 years ago. Germination is a natural biological process of plants by which the seeds come out of latency stage. Germination has profound effect on nutritional quality of the cereal. An advance treatment choice for CD is ¿Protease therapy¿ which uses particular protein hydrolysis enzymes to breakdown gluten peptides which are rich in proline content into small peptides which are not harmful to intestinal T. Germinated cereal proteases have distinctive benefits when compared to microbial and fungal peptidases. They are very good replacements to recombinant proteases especially to those patients of CD which are susceptible to those proteases and whose cost of production is very high